Page Title
Clinical Trial Finder
Genetic Therapy Enrolling
Study to evaluate KB407 in adults with cystic fibrosis (Krystal Bio KB407-02)
This study will evaluate safety and tolerability of ascending doses of nebulized KB407, a gene therapy intended to deliver a new, correct copy of the CFTR gene (DNA) to cells in adults with cystic fibrosis.
This is cohort 3 of a phase 1 study, with cohorts 1 and 2 already complete. All study participants will receive four administrations of the nebulized study drug KB407. Researchers will measure safety and tolerability by monitoring for changes from baseline in a participant’s physical exam, vital signs, ECG, and laboratory test results.
This study may require exams, blood draws, lung function tests, a bronchoscopy, and/or other measurements.
Email a research coordinator to express interest in participating in this study.
Eligibility
See other primary eligibility criteria for more information.
-
Age:
18 Years and Older -
Mutation(s):
No Mutation Requirement -
FEV1% Predicted:
50 to 100%
For a more comprehensive list of eligibility criteria and details on this study, visit ClinicalTrials.gov.
Other Primary Eligibility Criteria
This study is primarily enrolling participants that are not using CFTR modulators.
Study Design
-
Study Type: ?more info
Interventional -
Randomized Study: ?more info
No -
Placebo Controlled: ?more info
No -
Length of Participation:
3 months -
Number of Study Visits:
10
Additional Information
-
Phase: ?more info
Phase One -
Study Sponsor: ?more info
Krystal Bio -
Study Drugs:
Study Sites
-
Enrolling
Florida
University of Florida, Gainesville, FL 32610
Contact
Alexa Smith
Phone: +1
Email: alexa.howell@ufl.edu
-
Enrolling
North Carolina
Atrium Health Wake Forest Baptist, Winston-Salem, NC 27157
Contact
Christian Smith
Phone: +1 (336) 173-8550
Email: chnsmith@wakehealth.edu
Email a research coordinator to express interest in participating in this study.
Eligibility
See other primary eligibility criteria for more information.
-
Age:
18 Years and Older -
Mutation(s):
No Mutation Requirement -
FEV1% Predicted:
50 to 100%
For a more comprehensive list of eligibility criteria and details on this study, visit ClinicalTrials.gov.
Other Primary Eligibility Criteria
This study is primarily enrolling participants that are not using CFTR modulators.

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