Page Title
Drug Development Pipeline
Lonodelestat (formerly POL6014)
Status
Phase OneTherapeutic Approach
Anti-Inflammatory
Lonodelestat is a compound designed to block the function of neutrophil elastase. Neutrophil elastase is an enzyme that plays an essential role in inflammation. When the lungs are infected with bacteria, white blood cells release enzymes, including neutrophil elastase, to fight the infection. In CF, these enzymes can result in excessive inflammation that causes damage to the lungs. Blocking the function of neutrophil elastase may minimize tissue destruction and decrease inflammation within the CF airway.
Status
Phase 1 studies to test the safety of this compound are underway in Europe.
Sponsor
This program is sponsored by Santhera and partially funded by the Cystic Fibrosis Foundation.
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