ABBV-2222 (formerly GLPG2222) is a type of CFTR modulator called a corrector. Correctors are drugs designed to fix and restore the function of the defective CFTR protein. The corrected CFTR then moves to the cell surface, where it functions as a chloride channel and helps maintain the right balance of fluid in the airways.

Status

A phase 2a study to test the safety and tolerability of ABBV-2222 in people with CF who have two copies of the F508del CFTR mutation has been completed.

A phase 2 study to test ABBV-2222 in combination with ABBV-3067, a CFTR potentiator, is underway.

Sponsor

This program is sponsored by Abbvie and is being conducted within the Therapeutics Development Network.