GDC-6988 (formerly ETD002) is a compound designed to increase the activity of TMEM16A, a chloride channel found on the surfaces of airway cells. Similar to the CFTR channel, the TMEM16A channel helps regulate the amount of salt and fluids on the airway surface. Increasing the activity of TMEM16A may help increase the amount of fluid within the airways to improve mucus clearance.

Status

A phase 1 study to test the safety of GDC-6988 in healthy participants was completed.

Sponsor

This program is sponsored by Roche (Genentech) and partially funded by the Cystic Fibrosis Foundation.