Page Title
Drug Development Pipeline
GDC-6988 (formerly ETD002)
Status
DiscontinuedTherapeutic Approach
Mucociliary Clearance
GDC-6988 (formerly ETD002) is a compound designed to increase the activity of TMEM16A, a chloride channel found on the surfaces of airway cells. Similar to the CFTR channel, the TMEM16A channel helps regulate the amount of salt and fluids on the airway surface. Increasing the activity of TMEM16A may help increase the amount of fluid within the airways to improve mucus clearance.
Status
A Phase 1 study to test the safety of GDC-6988 in healthy participants is currently underway in the United Kingdom. The study is testing GDC-6988 alone and in combination with albuterol. No studies in CF are planned at this time.
Sponsor
This program is sponsored by Roche (Genentech) and partially funded by the Cystic Fibrosis Foundation.

CONTACT THE CLINICAL TRIAL NAVIGATOR
Get personalized assistance and answers to your clinical trial questions.
Learn MoreSign up for clinical trial alerts
Get email updates about clinical trials that matter to you.
Explore clinical trials
Be a part of the movement transforming the future of cystic fibrosis treatment.
Learn More