Page Title
Drug Development Pipeline
Opelconazole
Status
Phase ThreeTherapeutic Approach
Anti-Infective
This program is developing an inhaled drug (opelconazole) to prevent Aspergillus fungal infections in lung transplant recipients.
There are many challenges associated with current treatment options for people infected with Aspergillus. They may be hard to tolerate, which may lead many patients to discontinue use before they have completed the treatment’s course. Some current treatments may also interact with other common transplant medicines, resulting in potentially serious side effects.
This program will study whether inhaled opelconazole will be well tolerated and less likely to have drug-drug interactions. As an inhaled treatment option, it has the potential for being administered at home, instead of at a transplant or CF care center.
Status
A Phase 2 study to test the safety and tolerability of opelconazole in lung transplant recipients was completed. A Phase 3 study for people with refractory invasive pulmonary aspergillosis is currently underway. The study will test the safety and effectiveness of opelconazole in combination with existing standard-of-care systemic antifungal therapy vs. standard-of-care alone.
Sponsor
This program is sponsored by Pulmocide Limited and partially funded by the Cystic Fibrosis Foundation.

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