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Clinical Trial Finder
Blaze a trail to better treatments and a cure for cystic fibrosis.
As a clinical trial volunteer, you are paving the way for new treatments. Search or filter for trials that may be right for you, or learn more about what it means to be a trailblazer.
Showing 1-6 of 197 studies
As a clinical trial volunteer, you are paving the way for new treatments. Search for trials that may be right for you using the filter on the left, or learn more about what it means to be a trailblazer.
Showing 1-6 of 197 studies
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Restore CFTR FunctionEnrolling
Study of 4D-710 in Adults with Cystic Fibrosis , protocol number 4DMT 4D-710-C001This study will test the safety and tolerability of 4D-710, an investigational gene therapy, in adults with CF who are not eligible for or are unable to tolerate CFTR modulator therapy.
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Age:
18 Years and Older
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Mutation(s):
No Mutation Requirement
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FEV1% Predicted:
50 to 100%
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Number of Visits:
11
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Length of Participation:
2 years
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Anti-InflammatoryEnrolling
Study of INS1007/brensocatib tablets in adults with CF , protocol number Insmed INS1007-211This study will look at the safety, tolerability, and how the body processes INS1007/brensocatib tablets, a drug intended to reduce inflammation.
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Age:
18 Years and Older
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Mutation(s):
No Mutation Requirement
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FEV1% Predicted:
40 to 90%
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Number of Visits:
8
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Length of Participation:
56 days
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Anti-InfectiveEnrolling
Study to evaluate nebulized BX004-A in adults with cystic fibrosis and chronic Pseudomonas aeruginosa (BiomX Phase 1b/2a) , protocol number BiomX BMX-04-001 Part 1This study is testing the safety and tolerability of nebulized BX004-A, a bacteriophage drug intended to treat infections in the lung. Bacteriophages are specialized viruses that kill very specific bacterial strains. Multiple doses of the drug will be tested in adults with cystic fibrosis and chronic Pseudomonas aeruginosa (PsA) to find the best dose.
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Age:
18 Years and Older
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Mutation(s):
No Mutation Requirement
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FEV1% Predicted:
40% or greater
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Number of Visits:
7
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Length of Participation:
189 days
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Nutritional-GIEnrolling
Study to evaluate Creon in adults with cystic fibrosis or chronic pancreatitis , protocol number AbbVie M21-432This study will look at the symptoms of exocrine pancreatic insufficiency (EPI) in adults with cystic fibrosis or chronic pancreatitis treated with Creon with an alternate source of active drug. Creon is a drug approved to treat EPI.
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Age:
18 Years and Older
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Mutation(s):
No Mutation Requirement
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FEV1% Predicted:
No FEV1 Limit
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Number of Visits:
3
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Length of Participation:
142 days
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ObservationalEnrolling
Rare mutation cell collection (RARE) , protocol number RARE-OB-16This study is taking place at six regional care centers across the U.S. Researchers will collect and make available for study cells from people with rare CFTR mutations.
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Age:
12 Years and Older
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Mutation(s):
One Copy F508del or No Copies F508del
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FEV1% Predicted:
No FEV1 Limit
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Number of Visits:
1
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Length of Participation:
2 days
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OtherEnrolling
SIMPLIFY: Study to evaluate stopping inhaled hypertonic saline or dornase alfa in people with CF who are taking the triple-combination modulator, elexacaftor/tezacaftor/ivacaftor , protocol number SIMPLIFY-IP-19This study will test the effects and safety of stopping inhaled hypertonic saline or dornase alfa (Pulmozyme®) in teens and adults with CF who are also taking the triple-combination modulator, elexacaftor/tezacaftor/ivacaftor (Trikafta®). Trikafta® is intended to help CFTR function closer to normal, resulting in better clearance of mucus from the lungs. Inhaled hypertonic saline and dornase alfa are intended to thin airway surface liquid and improve clearance of mucus from the lungs. They are considered to be relatively burdensome therapies, so this study will look at the impact of stopping them in people who are also taking Trikafta®.
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Age:
12 Years and Older
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Mutation(s):
No Mutation Requirement
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FEV1% Predicted:
60% or greater
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Number of Visits:
4
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Length of Participation:
10 weeks
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Showing 1-6 of 197 studies
Studies in this tool are multi-center studies facilitated by the Cystic Fibrosis Therapeutics Development Network. For a complete list of cystic fibrosis related studies, visit www.clinicaltrials.gov.
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