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Observational Closed to Enrollment

Sweat chloride observational study (CHEC-OB-17)

This study is taking place at multiple care centers across the U.S. It will look at sweat chloride concentration in people who are currently taking CFTR modulators.

 Researchers will test the effectiveness of CFTR modulators by measuring change in sweat chloride concentration. Sweat chloride measures that are collected in the study visit will be analyzed in combination with data from the CF Foundation Patient Registry.This study is for people with cystic fibrosis who are enrolled in the CF Foundation Patient Registry and have been taking a CFTR modulator for at least three months before enrolling. This study will consist of a single study visit and will require a sweat test.

Eligibility

See other primary eligibility criteria for more information.

  • Age:

    4 Months and Older

  • Mutation(s):

    No Mutation Requirement

  • FEV1% Predicted:

    No FEV1 Limit

For more information about the results of this study and where it was conducted, visit ClinicalTrials.gov.

Other Primary Eligibility Criteria

Study participants must have current treatment with a commercially approved CFTR modulator for at least 3 months prior to enrollment.

Study Design

  • Study Type: ?more info

    Observational

  • Randomized Study: ?more info

    No

  • Placebo Controlled: ?more info

    No

  • Length of Participation:

    1 days

  • Number of Study Visits:

    1

Additional Information

  • Phase: ?more info

    Not Applicable

  • Study Sponsor: ?more info

    Hamblett, Nicole

  • Study Drugs:

    N/A

Study Sites

  • Closed to Enrollment

    Alabama

    The Children's Hospital Alabama, University of Alabama at Birmingham, Birmingham, AL 35233

  • Closed to Enrollment

    Arkansas

    University of Arkansas for Medical Sciences, Little Rock, AR 72205

  • Closed to Enrollment

    California

    University of California San Diego, La Jolla, CA 92093

  • Closed to Enrollment

    California

    Children's Hospital of Los Angeles, Los Angeles, CA 90027

  • Closed to Enrollment

    Colorado

    Children's Hospital Colorado, Aurora, CO 80045

  • Closed to Enrollment

    Colorado

    National Jewish Health, Denver, CO 80206

  • Closed to Enrollment

    Connecticut

    Yale University School of Medicine, New Haven, CT 06520

  • Closed to Enrollment

    Florida

    University of Florida, Gainesville, FL 32610

  • Closed to Enrollment

    Florida

    The Nemours Children's Clinic - Orlando, Orlando, FL 32827

  • Closed to Enrollment

    Florida

    Nemours Children's Health - Pensacola, Pensacola, FL 32514

  • Closed to Enrollment

    Georgia

    Children’s Healthcare of Atlanta and Emory University, Atlanta, GA 30322

  • Closed to Enrollment

    Georgia

    Emory University, Atlanta, GA 30324

  • Closed to Enrollment

    Illinois

    Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611

  • Closed to Enrollment

    Illinois

    University of Chicago, Chicago, IL 60637

  • Closed to Enrollment

    Indiana

    Riley Hospital for Children, Indianapolis, IN 46202

  • Closed to Enrollment

    Kansas

    University of Kansas Medical Center, Kansas City, KS 66160

  • Closed to Enrollment

    Kentucky

    University of Kentucky, Lexington, KY 40506

  • Closed to Enrollment

    Maryland

    Johns Hopkins University, Baltimore, MD 21287

  • Closed to Enrollment

    Massachusetts

    Boston Children's Hospital, Boston, MA 02115

  • Closed to Enrollment

    Massachusetts

    Massachusetts General Hospital, Boston, MA 02114

  • Closed to Enrollment

    Michigan

    Corewell Health Helen DeVos, Grand Rapids , MI 49503

  • Closed to Enrollment

    Michigan

    University of Michigan, Michigan Medicine, Ann Arbor, MI 48109

  • Closed to Enrollment

    Michigan

    Children's Hospital of Michigan, Detroit, MI 48201

  • Closed to Enrollment

    Minnesota

    The Minnesota Cystic Fibrosis Center, Minneapolis, MN 55455

  • Closed to Enrollment

    Missouri

    Children's Mercy Kansas City, Kansas City, MO 64108

  • Closed to Enrollment

    Missouri

    St. Louis Children's Hospital, St. Louis, MO 63110

  • Closed to Enrollment

    Missouri

    SSM Health Cardinal Glennon Children’s Hospital, St. Louis, MO 63104

  • Closed to Enrollment

    New Hampshire

    Dartmouth Hitchcock Medical Center, Lebanon, NH 03756

  • Closed to Enrollment

    New York

    New York Medical College at Westchester Medical Center, Valhalla, NY 10595

  • Closed to Enrollment

    New York

    The Cystic Fibrosis Center of Western New York, Buffalo, NY 14203

  • Closed to Enrollment

    North Carolina

    University of North Carolina at Chapel Hill, Chapel Hill, NC 27514

  • Closed to Enrollment

    Ohio

    Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229

  • Closed to Enrollment

    Ohio

    Children's Hospital Medical Center of Akron, Akron, OH 44308

  • Closed to Enrollment

    Ohio

    Toledo Children's Hospital, Toledo, OH 43606

  • Closed to Enrollment

    Ohio

    Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center, Cleveland, OH 44106

  • Closed to Enrollment

    Ohio

    Nationwide Children's Hospital, Columbus, OH 43205

  • Closed to Enrollment

    Oregon

    Oregon Health & Science University, Portland, OR 97239

  • Closed to Enrollment

    Pennsylvania

    Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224

  • Closed to Enrollment

    Pennsylvania

    Children's Hospital of Philadelphia, Philadelphia, PA 19104

  • Closed to Enrollment

    Pennsylvania

    Hershey Medical Center Pennsylvania State University, Hershey, PA 17033

  • Closed to Enrollment

    South Carolina

    Medical University of South Carolina, Charleston, SC 29425

  • Closed to Enrollment

    Tennessee

    Vanderbilt Children's Hospital, Nashville, TN 37232

  • Closed to Enrollment

    Tennessee

    University of Tennessee CF Care and Research Center, Memphis, TN 38103

  • Closed to Enrollment

    Texas

    Baylor College of Medicine, Houston, TX 77030

  • Closed to Enrollment

    Texas

    University of Texas Southwestern / Children’s Health, Dallas, TX 75207

  • Closed to Enrollment

    Texas

    University of Texas Southwestern, Dallas, TX 75390

  • Closed to Enrollment

    Utah

    Primary Children's Cystic Fibrosis Center, Salt Lake City, UT 84113

  • Closed to Enrollment

    Washington

    University of Washington Medical Center, Seattle, WA 98195

  • Closed to Enrollment

    Washington

    Seattle Children's Hospital, Seattle, WA 98105

  • Closed to Enrollment

    West Virginia

    West Virginia University - Morgantown, Morgantown, WV 26507

  • Closed to Enrollment

    Wisconsin

    Children's Wisconsin, Milwaukee, WI 53226

  • Closed to Enrollment

    Wisconsin

    University of Wisconsin, Madison, WI 53792

Eligibility

See other primary eligibility criteria for more information.

  • Age:

    4 Months and Older

  • Mutation(s):

    No Mutation Requirement

  • FEV1% Predicted:

    No FEV1 Limit

For more information about the results of this study and where it was conducted, visit ClinicalTrials.gov.

Other Primary Eligibility Criteria

Study participants must have current treatment with a commercially approved CFTR modulator for at least 3 months prior to enrollment.

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