Nitric oxide is a gas molecule produced by the body that plays a key role in the immune system. Nitric oxide has been shown to kill bacteria and break down their biofilms -- protective layers formed by bacteria that make them more difficult to eliminate. Researchers believe that increasing levels of nitric oxide in the body could help eliminate bacteria and increase lung function in people with CF. 

Status

A phase 2 study to test the safety and effectiveness of inhaled nitric oxide in adults with CF has been completed. No further development in CF is planned at this time.

Sponsor

This program was sponsored by Novoteris and partially funded by the Cystic Fibrosis Foundation. It was conducted within the Therapeutics Development Network.