SPX-101 is a compound designed to block the function of the sodium (Na+) channel found in the lungs. These channels move sodium and water away from the airway surface. Blocking these channels may help maintain fluid within the airways to improve mucus clearance. 

Status

Phase one and two studies to test the safety and effectiveness of SPX-101 were conducted outside of the US. No further development in CF is planned at this time.

Sponsor

This program was sponsored by Spyryx Biosciences and partially funded by the Cystic Fibrosis Foundation.