Page Title
Drug Development Pipeline
Nesolicaftor (PTI-428)
Status
DiscontinuedTherapeutic Approach
Restore CFTR Protein
Nesolicaftor is a type of modulator called an amplifier. Amplifiers increase the amount of CFTR protein in the cell. This makes more CFTR protein available for other therapies, such correctors and potentiators, to work on.
Status
Phase 2 studies were conducted to test the safety and effectiveness of nesolicaftor alone and in combination with two other CFTR modulators, posenacaftor (PTI-801) and dirocaftor (PTI-808). No further studies of these compounds are planned at this time.
Sponsor
This program was sponsored by Proteostasis Therapeutics. It was conducted through the Therapeutics Development Network.

CONTACT THE CLINICAL TRIAL NAVIGATOR
Get personalized assistance and answers to your clinical trial questions.
Learn MoreSign up for clinical trial alerts
Get email updates about clinical trials that matter to you.
Explore clinical trials
Be a part of the movement transforming the future of cystic fibrosis treatment.
Learn More